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b2m shrna lentiviral particles  (Santa Cruz Biotechnology)


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    Santa Cruz Biotechnology b2m shrna lentiviral particles
    Flow cytometric analysis of cell surface levels of ( A ) H-2K b and ( B ) CD80 in WT and αKO cells. The left panels show representative histograms and the right graphs show the mean ± SEM of the geometric means (geo. mean) of each flow cytometry distribution. H-2K b , n = 4; CD80, n = 3. *** P = 0.0007 (unpaired t test). ( C ) qRT-PCR analysis of mRNA expression of H-2K b , <t>B2m,</t> and CD80 in WT and αKO cells. Gene expression changes were normalized to Hprt . Graph shows mean ± SEM ( n = 6). **** P < 0.0001 (unpaired t test). ( D – F ) B6 mice were implanted with 0.5 million αKO/shB2m, αKO/CD80KO, or αKO/CD80KO+shB2m cells in the head of the pancreas and tumor growth was monitored by IVIS imaging. ( D ) Kaplan-Meier survival curves for αKO/shB2m, αKO/CD80KO, and αKO/CD80KO+shB2m mice. *A single mouse was euthanized for histology and removed from the study. Median survival: αKO/shB2m, 110.5 days; αKO/CD80KO+shB2m, 87.5 days. All αKO/CD80KO mice were alive at 115 days. P = 0.0026 (log-rank test). ( E ) Representative H&E and IHC images of pancreatic sections from αKO/shB2m or αKO/CD80KO+shB2m mice that died of tumor progression. Scale bar: 100 μm. ( F ) Representative H&E-stained pancreatic sections from a single αKO/shB2m mouse or αKO/CD80KO mice euthanized at 101 or 160 days, respectively. Scale bar: 100 μm.
    B2m Shrna Lentiviral Particles, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/%CE%B22+ar+shrna/pmc06668699-222-31-35?v=Santa+Cruz+Biotechnology
    Average 93 stars, based on 2 article reviews
    b2m shrna lentiviral particles - by Bioz Stars, 2026-07
    93/100 stars

    Images

    1) Product Images from "Tumor-intrinsic PIK3CA represses tumor immunogenicity in a model of pancreatic cancer"

    Article Title: Tumor-intrinsic PIK3CA represses tumor immunogenicity in a model of pancreatic cancer

    Journal: The Journal of Clinical Investigation

    doi: 10.1172/JCI123540

    Flow cytometric analysis of cell surface levels of ( A ) H-2K b and ( B ) CD80 in WT and αKO cells. The left panels show representative histograms and the right graphs show the mean ± SEM of the geometric means (geo. mean) of each flow cytometry distribution. H-2K b , n = 4; CD80, n = 3. *** P = 0.0007 (unpaired t test). ( C ) qRT-PCR analysis of mRNA expression of H-2K b , B2m, and CD80 in WT and αKO cells. Gene expression changes were normalized to Hprt . Graph shows mean ± SEM ( n = 6). **** P < 0.0001 (unpaired t test). ( D – F ) B6 mice were implanted with 0.5 million αKO/shB2m, αKO/CD80KO, or αKO/CD80KO+shB2m cells in the head of the pancreas and tumor growth was monitored by IVIS imaging. ( D ) Kaplan-Meier survival curves for αKO/shB2m, αKO/CD80KO, and αKO/CD80KO+shB2m mice. *A single mouse was euthanized for histology and removed from the study. Median survival: αKO/shB2m, 110.5 days; αKO/CD80KO+shB2m, 87.5 days. All αKO/CD80KO mice were alive at 115 days. P = 0.0026 (log-rank test). ( E ) Representative H&E and IHC images of pancreatic sections from αKO/shB2m or αKO/CD80KO+shB2m mice that died of tumor progression. Scale bar: 100 μm. ( F ) Representative H&E-stained pancreatic sections from a single αKO/shB2m mouse or αKO/CD80KO mice euthanized at 101 or 160 days, respectively. Scale bar: 100 μm.
    Figure Legend Snippet: Flow cytometric analysis of cell surface levels of ( A ) H-2K b and ( B ) CD80 in WT and αKO cells. The left panels show representative histograms and the right graphs show the mean ± SEM of the geometric means (geo. mean) of each flow cytometry distribution. H-2K b , n = 4; CD80, n = 3. *** P = 0.0007 (unpaired t test). ( C ) qRT-PCR analysis of mRNA expression of H-2K b , B2m, and CD80 in WT and αKO cells. Gene expression changes were normalized to Hprt . Graph shows mean ± SEM ( n = 6). **** P < 0.0001 (unpaired t test). ( D – F ) B6 mice were implanted with 0.5 million αKO/shB2m, αKO/CD80KO, or αKO/CD80KO+shB2m cells in the head of the pancreas and tumor growth was monitored by IVIS imaging. ( D ) Kaplan-Meier survival curves for αKO/shB2m, αKO/CD80KO, and αKO/CD80KO+shB2m mice. *A single mouse was euthanized for histology and removed from the study. Median survival: αKO/shB2m, 110.5 days; αKO/CD80KO+shB2m, 87.5 days. All αKO/CD80KO mice were alive at 115 days. P = 0.0026 (log-rank test). ( E ) Representative H&E and IHC images of pancreatic sections from αKO/shB2m or αKO/CD80KO+shB2m mice that died of tumor progression. Scale bar: 100 μm. ( F ) Representative H&E-stained pancreatic sections from a single αKO/shB2m mouse or αKO/CD80KO mice euthanized at 101 or 160 days, respectively. Scale bar: 100 μm.

    Techniques Used: Flow Cytometry, Quantitative RT-PCR, Expressing, Gene Expression, Imaging, Staining



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    Flow cytometric analysis of cell surface levels of ( A ) H-2K b and ( B ) CD80 in WT and αKO cells. The left panels show representative histograms and the right graphs show the mean ± SEM of the geometric means (geo. mean) of each flow cytometry distribution. H-2K b , n = 4; CD80, n = 3. *** P = 0.0007 (unpaired t test). ( C ) qRT-PCR analysis of mRNA expression of H-2K b , <t>B2m,</t> and CD80 in WT and αKO cells. Gene expression changes were normalized to Hprt . Graph shows mean ± SEM ( n = 6). **** P < 0.0001 (unpaired t test). ( D – F ) B6 mice were implanted with 0.5 million αKO/shB2m, αKO/CD80KO, or αKO/CD80KO+shB2m cells in the head of the pancreas and tumor growth was monitored by IVIS imaging. ( D ) Kaplan-Meier survival curves for αKO/shB2m, αKO/CD80KO, and αKO/CD80KO+shB2m mice. *A single mouse was euthanized for histology and removed from the study. Median survival: αKO/shB2m, 110.5 days; αKO/CD80KO+shB2m, 87.5 days. All αKO/CD80KO mice were alive at 115 days. P = 0.0026 (log-rank test). ( E ) Representative H&E and IHC images of pancreatic sections from αKO/shB2m or αKO/CD80KO+shB2m mice that died of tumor progression. Scale bar: 100 μm. ( F ) Representative H&E-stained pancreatic sections from a single αKO/shB2m mouse or αKO/CD80KO mice euthanized at 101 or 160 days, respectively. Scale bar: 100 μm.
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    Flow cytometric analysis of cell surface levels of ( A ) H-2K b and ( B ) CD80 in WT and αKO cells. The left panels show representative histograms and the right graphs show the mean ± SEM of the geometric means (geo. mean) of each flow cytometry distribution. H-2K b , n = 4; CD80, n = 3. *** P = 0.0007 (unpaired t test). ( C ) qRT-PCR analysis of mRNA expression of H-2K b , <t>B2m,</t> and CD80 in WT and αKO cells. Gene expression changes were normalized to Hprt . Graph shows mean ± SEM ( n = 6). **** P < 0.0001 (unpaired t test). ( D – F ) B6 mice were implanted with 0.5 million αKO/shB2m, αKO/CD80KO, or αKO/CD80KO+shB2m cells in the head of the pancreas and tumor growth was monitored by IVIS imaging. ( D ) Kaplan-Meier survival curves for αKO/shB2m, αKO/CD80KO, and αKO/CD80KO+shB2m mice. *A single mouse was euthanized for histology and removed from the study. Median survival: αKO/shB2m, 110.5 days; αKO/CD80KO+shB2m, 87.5 days. All αKO/CD80KO mice were alive at 115 days. P = 0.0026 (log-rank test). ( E ) Representative H&E and IHC images of pancreatic sections from αKO/shB2m or αKO/CD80KO+shB2m mice that died of tumor progression. Scale bar: 100 μm. ( F ) Representative H&E-stained pancreatic sections from a single αKO/shB2m mouse or αKO/CD80KO mice euthanized at 101 or 160 days, respectively. Scale bar: 100 μm.
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    Image Search Results


    Flow cytometric analysis of cell surface levels of ( A ) H-2K b and ( B ) CD80 in WT and αKO cells. The left panels show representative histograms and the right graphs show the mean ± SEM of the geometric means (geo. mean) of each flow cytometry distribution. H-2K b , n = 4; CD80, n = 3. *** P = 0.0007 (unpaired t test). ( C ) qRT-PCR analysis of mRNA expression of H-2K b , B2m, and CD80 in WT and αKO cells. Gene expression changes were normalized to Hprt . Graph shows mean ± SEM ( n = 6). **** P < 0.0001 (unpaired t test). ( D – F ) B6 mice were implanted with 0.5 million αKO/shB2m, αKO/CD80KO, or αKO/CD80KO+shB2m cells in the head of the pancreas and tumor growth was monitored by IVIS imaging. ( D ) Kaplan-Meier survival curves for αKO/shB2m, αKO/CD80KO, and αKO/CD80KO+shB2m mice. *A single mouse was euthanized for histology and removed from the study. Median survival: αKO/shB2m, 110.5 days; αKO/CD80KO+shB2m, 87.5 days. All αKO/CD80KO mice were alive at 115 days. P = 0.0026 (log-rank test). ( E ) Representative H&E and IHC images of pancreatic sections from αKO/shB2m or αKO/CD80KO+shB2m mice that died of tumor progression. Scale bar: 100 μm. ( F ) Representative H&E-stained pancreatic sections from a single αKO/shB2m mouse or αKO/CD80KO mice euthanized at 101 or 160 days, respectively. Scale bar: 100 μm.

    Journal: The Journal of Clinical Investigation

    Article Title: Tumor-intrinsic PIK3CA represses tumor immunogenicity in a model of pancreatic cancer

    doi: 10.1172/JCI123540

    Figure Lengend Snippet: Flow cytometric analysis of cell surface levels of ( A ) H-2K b and ( B ) CD80 in WT and αKO cells. The left panels show representative histograms and the right graphs show the mean ± SEM of the geometric means (geo. mean) of each flow cytometry distribution. H-2K b , n = 4; CD80, n = 3. *** P = 0.0007 (unpaired t test). ( C ) qRT-PCR analysis of mRNA expression of H-2K b , B2m, and CD80 in WT and αKO cells. Gene expression changes were normalized to Hprt . Graph shows mean ± SEM ( n = 6). **** P < 0.0001 (unpaired t test). ( D – F ) B6 mice were implanted with 0.5 million αKO/shB2m, αKO/CD80KO, or αKO/CD80KO+shB2m cells in the head of the pancreas and tumor growth was monitored by IVIS imaging. ( D ) Kaplan-Meier survival curves for αKO/shB2m, αKO/CD80KO, and αKO/CD80KO+shB2m mice. *A single mouse was euthanized for histology and removed from the study. Median survival: αKO/shB2m, 110.5 days; αKO/CD80KO+shB2m, 87.5 days. All αKO/CD80KO mice were alive at 115 days. P = 0.0026 (log-rank test). ( E ) Representative H&E and IHC images of pancreatic sections from αKO/shB2m or αKO/CD80KO+shB2m mice that died of tumor progression. Scale bar: 100 μm. ( F ) Representative H&E-stained pancreatic sections from a single αKO/shB2m mouse or αKO/CD80KO mice euthanized at 101 or 160 days, respectively. Scale bar: 100 μm.

    Article Snippet: Single cell clones were generated by serial dilution and confirmed by flow cytometry. αKO cells with reduced levels of B2m (referred to as αKO/shB2m) were generated by infecting αKO cells with B2m shRNA lentiviral particles (Santa Cruz Biotechnology, sc-29593-V).

    Techniques: Flow Cytometry, Quantitative RT-PCR, Expressing, Gene Expression, Imaging, Staining